Table 4 Parameters
Parameter | Presentation | Test |
|---|---|---|
PVPi (days 1, 2, 4, and 7) | Mean ± SD | Linear mixed model |
Oxygenation index (days 1, 2, 4, 7, 10, and 28) | Mean ± SD | Linear mixed model |
PaO2/FiO2 ratio (days 1, 2, 4, 7, 10, and 28) | Mean ± SD | Linear mixed model |
Airway driving pressure (days 1, 2, 4, 7, 10, and 28) | Mean ± SD | Linear mixed model |
Compliance (days 1, 2, 4, 7, 10, and 28) | Mean ± SD | Linear mixed model |
Mechanical power (days 1, 2, 4, 7, 10, and 28) | Mean ± SD | Linear mixed model |
SOFA score (days 1, 2, 4, 7, 10, and 28) | Mean ± SD | Linear mixed model |
Number of ventilator-free days (days 1 to 28) | Mean ± SD | T-test |
Duration of mechanical ventilation (days) (days 1 to 28) | Mean ± SD | T-test |
Length of ICU stay (days) (days 1 to 28) | Mean ± SD | T-test |
Hospital length of stay (days) (days 1 to 28) | Mean ± SD | T-test |
28-day mortality | Number (%) | Cox prop. Hazards |
Plasma biomarkers (days 1, 2, 4, 7, and 10) | Median ± IQR | MWU / Linear mixed model |
Blood cell counts (days 1, 2, 4, 7, and 10) | ||
RBC | Mean ± SD | Linear mixed model |
WBC | Mean ± SD | Linear mixed model |
Thrombocytes | Mean ± SD | Linear mixed model |
Kidney function (days 1, 2, 4, 7, and 10) | ||
Creatinine | Mean ± SD | Linear mixed model |
eGFR | Mean ± SD | Linear mixed model |
Liver enzymes (days 1, 2, 4, 7, and 10) | ||
ALT | Mean ± SD | Linear mixed model |
AST | Mean ± SD | Linear mixed model |
Bilirubin | Mean ± SD | Linear mixed model |
γ-glutamyl transferase | Mean ± SD | Linear mixed model |
Alkaline phosphatase | Mean ± SD | Linear mixed model |
NT-proBNP (days 1, 2, 4, 7, and 10) | Median ± IQR | Linear mixed model |
SAEs / AE | Number (%) | Descriptive |
ECG (ΔQTc time day 1 versus day 4) | Mean ± SD | T-test |