|
PVPi (days 1, 2, 4, and 7)
|
Mean ± SD
|
Linear mixed model
|
|
Oxygenation index (days 1, 2, 4, 7, 10, and 28)
|
Mean ± SD
|
Linear mixed model
|
|
PaO2/FiO2 ratio (days 1, 2, 4, 7, 10, and 28)
|
Mean ± SD
|
Linear mixed model
|
|
Airway driving pressure (days 1, 2, 4, 7, 10, and 28)
|
Mean ± SD
|
Linear mixed model
|
|
Compliance (days 1, 2, 4, 7, 10, and 28)
|
Mean ± SD
|
Linear mixed model
|
|
Mechanical power (days 1, 2, 4, 7, 10, and 28)
|
Mean ± SD
|
Linear mixed model
|
|
SOFA score (days 1, 2, 4, 7, 10, and 28)
|
Mean ± SD
|
Linear mixed model
|
|
Number of ventilator-free days (days 1 to 28)
|
Mean ± SD
|
T-test
|
|
Duration of mechanical ventilation (days) (days 1 to 28)
|
Mean ± SD
|
T-test
|
|
Length of ICU stay (days) (days 1 to 28)
|
Mean ± SD
|
T-test
|
|
Hospital length of stay (days) (days 1 to 28)
|
Mean ± SD
|
T-test
|
|
28-day mortality
|
Number (%)
|
Cox prop. Hazards
|
|
Plasma biomarkers (days 1, 2, 4, 7, and 10)
|
Median ± IQR
|
MWU / Linear mixed model
|
|
Blood cell counts (days 1, 2, 4, 7, and 10)
| | |
|
RBC
|
Mean ± SD
|
Linear mixed model
|
|
WBC
|
Mean ± SD
|
Linear mixed model
|
|
Thrombocytes
|
Mean ± SD
|
Linear mixed model
|
|
Kidney function (days 1, 2, 4, 7, and 10)
| | |
|
Creatinine
|
Mean ± SD
|
Linear mixed model
|
|
eGFR
|
Mean ± SD
|
Linear mixed model
|
|
Liver enzymes (days 1, 2, 4, 7, and 10)
| | |
|
ALT
|
Mean ± SD
|
Linear mixed model
|
|
AST
|
Mean ± SD
|
Linear mixed model
|
|
Bilirubin
|
Mean ± SD
|
Linear mixed model
|
|
γ-glutamyl transferase
|
Mean ± SD
|
Linear mixed model
|
|
Alkaline phosphatase
|
Mean ± SD
|
Linear mixed model
|
|
NT-proBNP (days 1, 2, 4, 7, and 10)
|
Median ± IQR
|
Linear mixed model
|
|
SAEs / AE
|
Number (%)
|
Descriptive
|
|
ECG (ΔQTc time day 1 versus day 4)
|
Mean ± SD
|
T-test
|
