Recruitment to a large scale randomised controlled clinical trial in primary care: the Helicobacter Eradication Aspirin Trial (HEAT)

Stevenson, Diane J.; Avery, Anthony J.; Coupland, Carol; Hobbs, F. D. Richard; Kendrick, Denise; Moore, Michael V.; Morris, Clive; Rubin, Greg P.; Smith, Murray D.; Hawkey, Christopher J.; Dumbleton, Jennifer S.

doi:10.1186/s13063-022-06054-w

Trials

Table 2 Participant recruitment in each region of the UK

From: Recruitment to a large scale randomised controlled clinical trial in primary care: the Helicobacter Eradication Aspirin Trial (HEAT)

Region	Total letters sent	Total reply slips received	Total expressions of interest (EOI)	EOI as a percentage of letters sent	Total¹ consented participants	Consented participants as a percentage of EOI	Total H. pylori-positive participants	H. pylori-positive participants as a percentage of consented participants
England
CRN E Midlands	20,242	8333	4051	20.0	3531	87.2	664	18.8
CRN Yorks & Humber	20,651	8306	4148	20.1	3023	72.9	606	20.0
CRN Wessex	19,070	8784	4250	22.3	3386	79.7	506	14.9
CRN Thames Valley & S Mids	9485	3946	2166	22.8	1698	78.4	249	14.7
CRN SW Peninsula	14,609	6511	3131	21.4	2631	84.0	418	15.9
CRN Eastern	14,732	6857	3728	25.3	2699	72.4	401	14.9
CRN W of England	13,248	5899	2885	21.8	2384	82.6	321	13.5
CRN NE & N Cumbria	8030	3142	1486	18.5	1154	77.7	283	24.5
CRN W Midlands	29,953	11,353	5046	16.8	4242	84.1	772	18.2
CRN Kent, Surrey, Sussex	9909	4723	2417	24.4	1653	68.4	256	15.5
CRN NW Coast	10,697	3604	1932	18.1	1312	67.9	305	23.2
CRN S London	3112	912	555	17.8	376	67.7	75	19.9
CRN N Thames	4314	1453	793	18.4	573	72.3	123	21.5
CRN NW London	974	252	134	13.8	80	59.7	26	32.5
CRN GTR Manchester	1897	592	284	15.0	222	78.2	53	23.9
Total in England	180,923	74,667	37,006	20.5	28,964	78.3	5058	17.5
Wales
Betsi Cadwaladr University LHB	1470	620	376	25.6	229	60.9	49	21.4
Cardiff and Vale University LHB	1118	453	223	19.9	155	69.5	43	27.7
Abertawe Bro Morgannwg University LHB	1277	595	373	29.2	242	64.9	50	20.7
Powys Teaching LHB	427	214	134	31.4	83	61.9	17	20.5
Aneurin Bevan LHB	816	270	157	19.2	104	66.2	31	29.8
Cwm Taf LHB	723	283	137	18.9	102	74.5	30	29.4
Hywel Dda LHB	209	62	35	16.7	28	80.0	9	32.1
Total in Wales	6040	2497	1435	23.8	943	65.7	229	24.3
Northern Ireland
Belfast HSCT	88	29	26	29.5	25	96.2	6	24.0
Southeastern HSCT	609	181	119	19.5	107	89.9	28	26.2
Northern HSCT	305	111	69	22.6	68	98.6	20	29.4
Total in Northern Ireland	1002	321	214	21.4	200	93.5	54	27.0
Scotland
Tayside² LHB	261	71	23	8.8	6	26.1	0	0.0
Lanarkshire LHB	649	198	93	14.3	53	57.0	23	43.4
Total in Scotland	910	269	116	12.7	59	50.9	23	39.0
Total in UK	188,875	77,754	38,771	20.5	30,166	77.8	5364	17.8

¹A consented participant was defined as one with a valid signed Informed Consent Form and a Data Capture Record form completed at screening and entered on the HEAT database
²Tayside LHB withdrew from the trial shortly after starting recruitment due to staffing problems

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ISSN: 1745-6215

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