Table 1 Referrals and inclusions*

Estimated population on 1/1/2012 aged 50–79 in all five regions^†

5,284,676

1,316,362

945,173

1,295,626

211,983

1,515,531

Estimated eligible patients during trial^‡

6589

1641

1178

1615

264

1890

Referred (% estimated eligible)

766 (11.6)

317 (19.3)

103 (8.7)

166 (10.3)

79 (29.9)

100 (5.3)

1

Included patients (% included of referred)

446 (58.2)

190 (59.9)

51 (49.5)

97 (58.4)

47 (59.5)

61 (61.0)

Not included

Reason (% of not included patients)

Unknown^§

133 (41.6)

35 (10.9)

20 (6.3)

59 (18.4)

9 (2.8)

9 (2.8)

1 (0.3)

Exclusion criterion^‖

53 (16.6)

24 (7.5)

9 (2.8)

4 (1.3)

8 (2.5)

8 (2.5)

Too taxing**

41 (12.8)

15 (4.7)

9 (2.8)

2 (0.6)

7 (2.2)

8 (2.5)

Patient wanted to start with medication**

39 (12.2)

20 (6.3)

8 (2.5)

1 (0.3)

1 (0.3)

9 (2.8)

Patient did not want medication**

35 (10.9)

24 (7.5)

1 (0.3)

2 (0.6)

3 (0.9)

5 (1.6)

Afraid of side-effects**

6 (1.9)

3 (0.94)

3 (0.94)

Patient could not be reached‖

4 (1.3)

2 (0.6)

1 (0.3)

1 (0.3)

Research nurse did not receive referral**

2 (0.6)

2 (0.6)

Participation in other clinical research‖

2 (0.6)

1 (0.3)

1 (0.3)

Extended stay outside Netherlands^‖

2 (0.6)

1 (0.3)

1 (0.3)

Patient not convinced of PD-diagnosis**

1 (0.3)

1 (0.3)

Only wants to participate if unblinded**

1 (0.3)

1 (0.3)

Time to contact patient took too long**

1 (0.3)

1 (0.3)

% of unknown reason relative to number of non-inclusion

41.6%

27.6%

38.5%

85.5%

28.1%

23.1%