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Table 3 Power available for various aggregate seroconversion rates and effect sizes. Note: The interim seroconversion rate in the control arm was derived algebraically from the observed aggregate rate and the effect size

From: EVITA Dengue: a cluster-randomized controlled trial to EValuate the efficacy of Wolbachia-InfecTed Aedes aegypti mosquitoes in reducing the incidence of Arboviral infection in Brazil

Interim aggregate seroconversion rate (threshold for stopping) 50% effect size 40% effect size 30% effect size
Interim seroconversion rate in control arm Power Interim seroconversion rate in control arm Power Interim seroconversion rate in control arm Power
10% 13% 81% 12% 56% 12% 32%
15% 20% 95% 19% 76% 18% 47%
20% 27% 99% 25% 89% 24% 61%
25% 33% > 99% 31% 96% 29% 74%
30% 40% > 99% 37% 99% 35% 84%
33% 44% > 99% 41% 99% 39% 88%
34% 45% > 99% 42% 99% 40% 90%
35% 47% > 99% 44% > 99% 41% 91%
40% 53% > 99% 50% > 99% 47% 96%