Individualized positive end-expiratory pressure guided by end-expiratory lung volume in early acute respiratory distress syndrome: study protocol for the multicenter, randomized IPERPEEP trial

Table 1 Computed respiratory mechanics parameters

Parameter	Formula
Airway driving pressure	ΔP = Pplat_aw − PEEP_aw
Transpulmonary end-inspiratory pressure	Pplat_L = Plat_aw − Pplat_es
Transpulmonary end-expiratory pressure	PEEP_L = PEEP_aw − PEEP_es
Lung driving pressure	ΔP_L = Pplat_L − PEEP_L
Lung plateau pressure, elastance-derived	Pplat_L,EL = Pplat_aw × (ΔP_L/ΔP)
Static respiratory system compliance	Cst_RS = V_T/ΔP
Static lung compliance	Cst_L = V_T/ΔP_L
Static chest wall compliance	Cst_CW = V_T/(Pplat_es − PEEP_es)
Oxygenation-stretch index	OSI = PaO₂/(FiO₂ × ΔP)
Dynamic strain	Dynamic strain = V_T/FRC_PEEPset
Static strain (strain due to PEEP)	Static strain = (PEEP_volume − Rec_ZEEP-PEEP)/FRC_PEEPset
Static stress (stress due to PEEP)	Static stress = PEEP_aw × (ΔP_L/ΔP)
Dynamic stress	Dynamic stress = Pplat_aw × (ΔP_L/ΔP)

ISSN: 1745-6215