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Table 5 Secondary outcome analysis

From: Effectiveness of the Shenzhuo formula in the treatment of patients with macroalbuminuria secondary to diabetic kidney disease: protocol update and statistical analysis plan

Time point

SZF, number, mean (SD)

Irbesartan, number, mean (SD)

Mean difference (95% CI)

p Value

Scr at

n = xx

n = xx

  

Week 0

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 4

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 8

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 12

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 16

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 20

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 24

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Overall SZF effect a

  

.xx

eGFR at

n = xx

n = xx

  

Week 0

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 4

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 8

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 12

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 16

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 20

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 24

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Overall SZF effect

  

.xx

UAER at

n = xx

n = xx

  

Week 0

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 4

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 8

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 12

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 16

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 20

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 24

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Overall SZF effect

  

.xx

FBG

n = xx

n = xx

  

Week 0

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 4

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 8

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 12

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 16

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 20

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 24

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Overall SZF effect

  

.xx

2hPG at

n = xx

n = xx

  

Week 0

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 4

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 8

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 12

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 16

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 20

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 24

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Overall SZF effect

  

.xx

TC at

n = xx

n = xx

  

Week 0

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 12

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 24

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Overall SZF effect

  

.xx

TG at

n = xx

n = xx

  

Week 0

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 12

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 24

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Overall SZF effect

  

.xx

LDL at

n = xx

n = xx

  

Week 0

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 12

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 24

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Overall SZF effect

  

.xx

HDL at

n = xx

n = xx

  

Week 0

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 12

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 24

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Overall SZF effect

  

.xx

HbA1c at

n = xx

n = xx

  

Week 0

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 12

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 24

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Overall SZF effect

  

.xx

BP at

n = xx

n = xx

  

Week 0

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 4

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 8

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 12

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 16

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 20

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 24

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Overall SZF effect

  

.xx

ACR at

n = xx

n = xx

  

Week 0

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 4

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 8

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 12

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 16

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 20

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 24

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Overall SZF effect

  

.xx

ADDQoL at

n = xx

n = xx

  

Week 0

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 12

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Week 24

xx (xx)

xx (xx)

xx (xx to xx)

.xx

Overall SZF effect

   

.xx

  1. ap values comparing between-group differences over the entire 24-week trial