Table 1 Questions to guide research teams in designing and delivering remote trials

1. Do you need to change the way in which you identify potential participants? Has the clinical care pathway changed?

2. What are the infrastructure requirements for the proposed method of delivery (hardware, software, connectivity)? Are these supported by your organisation and available to potential participants?

3. Will Remote Trial Delivery introduce bias? If so, how can this be mitigated?

4. Are you able to provide participants with guidance and support in using the remote methods?

5. How will you ensure participants feel supported and have the opportunity to ask questions?

6. What training provision is there for your team and participants in any new methodologies?

7. Are the interventions, assessments and outcome measures validated for the planned use?

8. Will some aspects of trial delivery be more difficult (e.g. some safety assessments)? How will this be mitigated?

9. Are there any concerns regarding data security as a result of remote delivery?

10. Do you need to adapt your processes to ensure data integrity?

11. What additional processes for PI oversight do you need to develop?