Atorvastatin combined with dexamethasone in chronic subdural haematoma (ATOCH II): study protocol for a randomized controlled trial

Table 1 Visit and assessment schedule

Items	Screen	Day 1	Day 7 ± 1	Day 14 ± 1	Day 28 ± 3	Day 90 ± 7	Day 180 ± 7
Informed consent	×
Inclusion/exclusion^a	×
Filling general information	×
Collect medical history	×
Concomitant medications^b	×	×	×	×	×
Physical examination	×
Surgery		×	×	×	×	×	×
Neurological symptoms^c	×	×	×	×	×	×	×
Haematoma volume^c	×			×	×	×
mRS^c	×				×	×	×
ADL-BI					×	×	×
Blood routine	×	×		×	×
Biochemistry	×	×		×	×
Coagulation	×	×		×	×
Vital signs^c	×	×	×	×	×
Electrocardiography	×			×	×
Adverse events		×	×	×	×	×	×
Allocate random number	×
Drug recycling^d	×	×	×	×	×

ADL-BI activities of daily life on the Barthel Index, mRS modified Rankin scale
^aAccreditation of laboratory examination within 3 days, including head CT, before enrolment
^bCombined use of drugs before commencing study treatment and continue until the end of the 28-day treatment period
^cDuring conservative treatment, if a participant’s neurological function deteriorates associated with an increase in the size of the haematoma and risk of cerebral herniation, they must change over to surgical treatment
^dRemaining drugs are to be recycled

ISSN: 1745-6215