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Fig. 3 | Trials

Fig. 3

From: Safety and efficacy of C1-inhibitor in traumatic brain injury (CIAO@TBI): study protocol for a randomized, placebo-controlled, multi-center trial

Fig. 3

SPIRIT diagram of the recommended content for the schedule of enrollment, interventions, and assessments. Abbreviations: C1-INH, complement 1-inhibitor; TIL, therapy intensity level; (S)AEs, (serious) adverse events; ICP, intracranial pressure; CT, computed tomography; ICU, intensive care unit; LOS, length of stay; GOSE, Glasgow Outcome Scale Extended; QoLiBri, Quality of Life after Brain Injury Scale; iPCQ, iMTA Productivity Cost Questionnaire; iMCQ, iMTA Medical Cost Questionnaire; SF-36, Short-Form 36; EQ-5D-5L, 5 Level EuroQoL 5-Dimensional Questionnaire

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