Fig. 1
From: The design of a Bayesian adaptive clinical trial of tranexamic acid in severely injured children
Nine scenarios are presented to understand the operating characteristics of the model. Effect sizes for the PedsQL AUC compared to the placebo arm are plotted for each dose for the Brain, Torso, and Both injury groups. Lines above zero on the vertical axis indicate efficacious scenarios where flat lines at zero indicate the null scenario (no benefit). Lines below zero on the vertical axis indicate harmful scenarios