Table 1 Schedule of assessments

Informed consent for trial participation

x

Eligibility (pregnancy test, drug screening, inclusion, & exclusion criteria)

x

Buccal swab (Stratipharm®)

x

Medical history (previous antidepressant therapies)

x

Lab values (basic hematology, creatinine (eGFR), ASAT, ALAT, total bilirubin, gamma-GT, CRP, TSH, vit. B12, and vit. D)

x

x

Concomitant medication documentation

x

x

x

x

x

x

x

x

RANDOMIZATION (only if new antidepressant indicated)

x

PGx pharmaceutical recommendation (only arm A)

x

Start NEW antidepressant

x

HAM-D17

x

x^a

x^c

x

x^c

x

x

x

AE assessment (antidepressant therapy only)

x^c

x

x^c

x

x

x

FIBSER patient self-assessment

x^a

x^c

x

x^c

x

x

x

BDI-II patient self-assessment

x^a

x

x

x^b

x

Blood sample collection (EDTA and serum)

x

x