Salvage hypofractionated accelerated versus standard radiotherapy for the treatment of biochemical recurrence after radical prostatectomy (SHARE): the protocol of a prospective, randomized, open-label, superiority, multi-institutional trial

Table 3 Equivalent dose in 2-Gy fractions (EQD2) and biologically effective dose (BED) calculations

	Conventionally fractionated (66 Gy in 33 fractions)	Hypofractionated (65 Gy in 26 fractions)
EQD2^a (Gy)
Prostate cancer	66	74.29
Early-responding normal tissue	66	67.71
Late-responding normal tissue	66	71.5
BED^a (Gy)
Prostate cancer	154	173.33
Early-responding normal tissue	79.2	81.25
Late-responding normal tissue	110	119.17

^aα/β ratio for prostate cancer is 1.5, 10 for early-responding normal tissue, and 3 for late-responding normal tissue

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