Table 5 Appraisal of FaCe-Man trial

Problem base

Considering the prevalence and chronicity of MNP *, it needs to be addressed.

Context placement

Systematic assessment of prior evidence reveals a research gap

Information gain

Large enough to be informative

Pragmatism

Pragmatic approach to reflect the real life

Patient-centeredness

Patient centric

Value for money

Focuses on larger group of population with MNP

Feasibility

Feasible

Transparency

Method, data, and analyses will be verifiable and unbiased