Evaluating newly approved drugs for multidrug-resistant tuberculosis (endTB): study protocol for an adaptive, multi-country randomized controlled trial

Table 1 Description of endTB treatment arms {11a}

Trial regimens	Bedaquiline	Delamanid	Clofazimine	Linezolid	Fluoroquinolone	Pyrazinamide
endTB 1	Bdq			Lzd	Mfx	Z
endTB 2	Bdq		Cfz	Lzd	Lfx	Z
endTB 3	Bdq	Dlm		Lzd	Lfx	Z
endTB 4		Dlm	Cfz	Lzd	Lxf	Z
endTB 5		Dlm	Cfz		Mfx	Z
endTB 6 (Control)	Standard of care control, composed according to latest WHO Guidelines, including the possible use of Dlm or Bdq.

Abbreviations: Bdq, bedaquiline; Dlm, delamanid; Cfz, clofazimine; Lzd, linezolid; Mfx, moxifloxacin; Lfx, levofloxacin; Z, pyrazinamide

ISSN: 1745-6215