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Table 1 Inclusion and exclusion criteria

From: Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial

Inclusion criteria

Exclusion criteria

An out-of-hospital cardiac arrest with return of spontaneous circulation (ROSC);

Ventricular fibrillation (VF) or ventricular tachycardia (VT) as first registered cardiac rhythma;

Glasgow Coma Scale (GCS) ≤8b.

Terminal renal insufficiency, i.e., receiving renal replacement therapy (RRT);

Known glucose 6-phosphate dehydrogenase deficiency (risk of hemolysis);

History of urolithiasis, oxalate nephropathy, or hemochromatosis;

Treatment limitationsc.

  1. aIf an automated external defibrillator advised to shock, then VF or VT was registered by the device.
  2. bThe last GCS-score before the start of sedatives will be used.
  3. cThe presence of treatment limitations will only be assessed at the moment of randomization.