Table 5 Biomarker parameters recorded at time of admission (baseline) and at time of discharge from hospital (endpoint)
Arm I: Placebo Mean (SD) | Arm II: NVK Mean (SD) | Arm III: KSK Mean (SD) | P value | |
|---|---|---|---|---|
IL 6 baseline (n=38, 39, 34) | 7.5 (4.4) | 5.7 (4.2) | 7.1 (4.0) | 0.09 |
IL 6 endpoint (n=38, 39, 38) | 4.0 (2.9) | 2.6 (2.5) | 2.2 (1.3) | 0.02 |
LDH baseline (n=26, 25, 22) | 17.2 (3.5) | 16.6 (4.6) | 17.3 (5.8) | 0.61 |
LDH endpoint (n=24, 17, 13) | 17.4 (5.6) | 17.3 (3.9) | 13.2 (5.6) | 0.10 |
Ferritin baseline (n=26, 25, 21) | 10.5 (4.5) | 11.7 (5.3) | 13.2 (5.8) | 0.25 |
Ferritin endpoint (n=23, 16, 11) | 11.4 (5.0) | 11.0 (5.7) | 10.6 (5.3) | 0.95 |
D dimer baseline (n=26, 21, 13) | 0.9 (0.7) | 1.9 (3.6) | 2.7 (6.8) | 0.79 |
D dimer endpoint (n=16, 15, 7) | 2.6 (4.8) | 1.6 (2.6) | 3.7 (7.5) | 0.53 |
CRP baseline (n=24, 25, 22) | 3.5 (2.8) | 3.0 (2.4) | 2.6 (1.5) | 0.84 |
CRP endpoint (n=22, 19, 15) | 3.9 (3.2) | 2.5 (1.6) | 3.1 (4.7) | 0.26 |