1 | Participants experiencing serious adverse reactions during the study |
2 | Fatal comorbidities happen, including but not limited to severe infection |
3 | Participants whose condition deteriorates within the first 24 week |
4 | Participants who fail to achieve remission (CR or PR) until the end of week 24 |
5 | Pregnant |
6 | Any other circumstances under which the investigator considers the patient to be unable to finish the study |