Effects of moderate-intensity intermittent hypoxic training on health outcomes of patients recovered from COVID-19: the AEROBICOVID study protocol for a randomized controlled trial

Table 2 Schedule of enrolment, interventions, and assessments

Timepoint	Study period
	Enrolment	Allocation	Post-allocation
	-t₁	0	*Baseline*	*Partial evaluation* *(week 5)*	*Post-training* *(week 9)*	*After 4 weeks of training end (week 13)*
Enrolment
Eligibility screen	X
Informed consent	X
Allocation		X
Interventions (training)
*Normoxia (N)*			X
*Hypoxia (H)*			X
*Hypoxia recovery (HR)*			X
*Control group*			X
Assessments
*Lung function (spirometry)*			X	X	X	X
*Autonomic parameters (HRV)*			X	X	X	X
*Max Aerobic power (VO₂peak)*			X	X	X	X
*Anaerobic threshold*			X	X	X	X
*Inflammatory mediators*¹			X		X	X
*Haematological parameters*²			X		X	X
*Body composition (iDXA)*			X		X	X
*Quality of life (SF – 12)*			X		X	X
*Mental Health (DASS–21)*			X		X	X
*Anthropometric (BMI, WC)*			X		X	X
*Physical fitness (motor tests)*			X		X	X

HRV heart rate variability, max maximum, BMI body mass index, WC waist circumference
¹Inflammatory mediators include quantification of cytokines and profile of eicosanoids
²Haematological parameters include complete blood cell count, total cholesterol, triglycerides, HDL-c, LDL-c, lactate dehydrogenase, liver enzymes (alanine aminotransferase and aspartate aminotransferase), and EPO

ISSN: 1745-6215