Table 1 Inclusion and exclusion criteria
Group | Criterion | Definition |
|---|---|---|
Inclusion (determined on admission to PICU) | ||
Age | Birth to < 16 years of age | |
Location | Admitted to PICU | |
Time frame | New admission to PICU within the last 24 h and has received IVFT for ≤ 4 h in PICU | |
Decision—clinician decides that IVFT is required | IVFT—all intravenous fluids (boluses and maintenance fluids but not drug dilutions) administered in PICU | |
Biochemistry | Admission sodium > 130 mmol/L (measured on admission or no longer than 48 h before randomization) | |
Exclusion | ||
Age | ≥ 16 years | |
Time frame | Received IVFT for > 4 h in PICU | |
Pre-existing conditions | - Admitted for a cardiac condition - Chronic kidney disease | |
Disease-specific IVFT protocols | - Traumatic brain injury or at risk of cerebral oedema - Burns - Post-liver transplant - Post-renal transplant - Diabetic ketoacidosis - Oncology patients needing hyperhydration | |