Table 3 Univariable and multivariable meta-regression

Univariable meta-regression

% censoring

Average risk ratio

0.974 [0.964; 0.983]

2.308 [2.217; 2.403]

1.257 [1.226; 1.288]

1.101 [1.086; 1.116]

1.201 [1.175; 1.228]

10% increase

0.999 [0.996; 1.002]

0.916 [0.903; 0.929]

0.973 [0.965; 0.980]

1.026 [1.021; 1.031]

0.979 [0.972; 0.986]

%CEs

Average risk ratio

0.976 [0.969; 0.984]

2.191 [2.141; 2.243]

1.240 [1.214; 1.267]

1.124 [1.109; 1.140]

1.190 [1.168; 1.213]

10% increase

1.003 [1.000; 1.006]

1.127 [1.117; 1.138]

1.036 [1.028; 1.045]

0.977 [0.971; 0.982]

1.029 [1.021; 1.036]

Size of AE

Average risk ratio

0.973 [0.966; 0.980]

2.105 [2.005; 2.210]

1.215 [1.185; 1.246]

1.131 [1.112; 1.150]

1.171 [1.146; 1.197]

probability

increase of 0.1

0.996 [0.992; 1.000]

0.954 [0.930; 0.980]

0.995 [0.982; 1.008]

0.993 [0.984; 1.003]

0.993 [0.982; 1.004]

Evaluation

Average risk ratio

0.972 [0.964; 0.980]

2.094 [1.994; 2.199]

1.214 [1.184; 1.244]

1.131 [1.112; 1.150]

1.170 [1.145; 1.195]

time

one additional year

0.993 [0.987; 1.000]

1.054 [1.021; 1.087]

1.015 [0.999; 1.033]

0.996 [0.986; 1.007]

1.013 [0.998; 1.027]

Multivariable meta-regression

Average risk ratio

0.976 [0.966; 0.985]

2.407 [2.348; 2.468]

1.277 [1.246; 1.308]

1.097 [1.082; 1.113]

1.218 [1.192; 1.245]

%censoring 10% increase

0.997 [0.994; 1.000]

0.890 [0.882; 0.899]

0.965 [0.957; 0.973]

1.028 [1.023; 1.034]

0.972 [0.965; 0.979]

Size of AE probability increase of 0.1

0.995 [0.991; 0.999]

0.893 [0.882; 0.904]

0.972 [0.961; 0.983]

1.008 [1.000; 1.016]

0.975 [0.965; 0.985]

Evaluation time one additional year

0.994 [0.988; 1.000]

1.036 [1.021; 1.051]

1.014 [1.000; 1.027]

1.003 [0.995; 1.011]

1.011 [0.999; 1.024]