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Table 1 Timeline and assessment schedule for the L-ZIP study

From: The Lutein and Zeaxanthin in Pregnancy (L-ZIP) study—carotenoid supplementation during pregnancy: ocular and systemic effects—study protocol for a randomized controlled trial

 

Screening/baseline

Maternal Supplementation

Visit

Timeframe

T1

T2

T3

Birth

Before 14 Wks. GA

22–26 Wks. GA

37–39 Wks. GA

0 to 2 Wks.

Informed consent

X

   

Randomization

X

   

Maternal visual acuity and contrast sensitivity

X

X

X

X

Maternal nutritional surveys

X

X

X

X

Dilated eye examination

X

X

X

X

Maternal serum carotenoids

X

X

X

X

Maternal macular pigment imaging

X

X

X

X

Maternal skin carotenoids

X

X

X

X

Dispense prenatal supplement and do pill counts

X

X

X

X

Infant cord blood carotenoids

   

X

Infant macular pigment imaging

   

X

Infant foveal imaging (SD-OCT)

   

X

Infant skin carotenoids

   

X

  1. T1, first trimester; T2, second trimester; T3, third trimester; Wks., weeks; GA, gestational age; SD-OCT, spectral-domain optical coherence tomography
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Trials

ISSN: 1745-6215