Table 2 Summary of features of identified software of immediate interest. A checkmark represents an available feature, a checkmark in parentheses represents a partly available feature, a wave stands for a feature for which it is foreseen that the user includes it by writing additional code and an x represents an unavailable feature. Software is grouped into standalone software, packages for R and Stata and online trial simulators. MD Anderson is the abbreviation of Integrated Platform for Designing Clinical Trials

Flexibility arms

Options regarding the number of treatment arms at the start of the trial

✔

✔

✔

✔

✔

✔

✔

✔

✔

Staggered entry

Options regarding the staggered entry of treatments over time, such as pre-planned, randomly, replacing treatments, ...

x

x

x

∼

x

x

x

x

(✔)

Endpoints

Choice, e.g., binary, continuous, time-to-event

✔

✔

✔

✔

✔

✔

✔

✔

x

Surrogate endpoint

Option to use different endpoint at interim

✔

(✔)

x

∼

✔

✔

✔

✔

x

Interims

Options regarding the number and timing of interim analyses

✔

✔

✔

✔

✔

✔

x

✔

✔

Enrichment/seamless

Dedicated options for treatment selection or enrichment at interim

✔

✔

✔

∼

x

x

✔

x

x

Bayesian

Bayesian decision rules

✔

x

x

✔

x

x

x

✔

✔

Frequentist

Frequentist decision rules

✔

✔

✔

∼

✔

✔

✔

x

x

Flexibility data sharing

Advanced options for data sharing, such as sharing control data, sharing only concurrent control data, dynamic borrowing, etc.

x

x

x

(✔)

x

x

x

x

x

Multiplicity correction

Options for multiplicity correction, e.g., control of FWER, FDR, ...

x

✔

✔

∼

(✔)

✔

✔

x

x

Flexibility allocation ratio

Options regarding the allocation ratio of patients to the arms

✔

(✔)

(✔)

∼

✔

✔

x

(✔)

✔

RAR

Response-adaptive randomization

✔

x

x

∼

x

x

x

✔

✔

Flexibility cohort structure

Options for designing exact cohort structure to enter/leave platform, e.g., always control and two experimentals, ...

x

x

x

x

x

x

x

x

x

Flexibility recruitment rate

Options regarding the recruitment rate of patients to the trial

✔

(✔)

✔

✔

✔

x

x

x

x

Comparison classical development program

Built-in options regarding the comparison with more classical designs

x

x

x

x

x

x

x

(✔)

x

GUI

Graphical user interface

✔

✔

✔

x

✔

x

x

✔

✔

Commercial

Software is commercial

✔

✔

✔

x

x

x

x

x

x

Open Source

Open source code available

x

x

x

✔

✔

✔

✔

✔

x