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Cascade of care for the initiation and completion of TPT of child contacts < 5 years or HIV-infected 5–14 years and reasons of dropouts at different steps of the cascade
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Number of screened children and proportion of children screened among child contacts < 5 years or HIV-infected 5–14 years declared by the index case
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Proportion of children potentially eligible for TPT: TB disease excluded
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Proportion of children eligible for TPT after exclusion of contraindication to TPT
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Proportion of children started on TPT among those eligible for TPT
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Proportion of children who did not complete TPT among those started on TPT and reasons of interruptions
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Cascade of care for TB detection of child contacts
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Proportion of children with symptoms suggestive of TB: presumptive TB
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Proportion of presumptive TB cases investigated for TB
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Proportion of children diagnosed with TB
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Proportion of children with TB diagnosis who are started on TB treatment
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Cascade of care for TB detection of adult contacts
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Number of adults screened and proportion of adults screened among household identified adult contacts
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Proportion of adults with symptoms suggestive of TB: presumptive TB cases
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Proportion of adults presumptive TB cases diagnosed with TB
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Safety and treatment adherence for children under TPT
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Proportion of children with serious adverse events
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Proportion of children with adverse events of interest: peripheral neuropathy, clinical hepatotoxicity
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Ratio of dose taken as indicated (ticked) on the treatment card by the parent/guardian over the total number of doses to be taken by prescription
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Endpoints at 6 months
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Treatment outcomes of children started on TB treatment
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Proportion of children diagnosed with TB after initiation of TPT: during and after TPT
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Proportion of children diagnosed with TB among those who were not started on TPT and were not diagnosed with TB at baseline assessment
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Before-after comparison for TB adult and pediatric cases and for TPT initiation and completion from health facility registers
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Number of patients diagnosed with TB and registered
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Proportion of children among all patients diagnosed with TB and registered
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TB treatment outcomes of patients (adults and children) diagnosed with TB and registered
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Number of children started on TPT
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Completion rate of children started on TPT
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Acceptability and feasibility of the intervention
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Attitudes, willingness, and motivation to have a visit in their household
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Myths, anticipated fears, stigma, and risks of having a visit in their household
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Actual experiences with household visits
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Perception of the disease, its risk, and the notion of prevention, including TPT
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Description of critical events during house visits and how these were dealt with
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Identification of main constraints
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Fidelity of the study
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Proportion of delivered activities compared to the intended activities of the model
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Cost-effectiveness of the intervention
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Costs of CHW/community nurse assessment and treatment
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Costs of facility-based assessment and treatment
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Other facility costs (overheads, diagnosis, hospitalizations)
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Direct parent/guardian costs (related to care)
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Indirect parent/guardian costs (unrelated to care, e.g., dissaving, travel costs)
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