Table 1 Timeline of events in the trial

Time point

− 1

0

D1–D4

D5–D7

D8–D14

D15–D28

 Screening

x

 Eligibility criteria

x

 Informed consent

x

 Allocation

x

 Randomization

x

 Baseline data collection

x

 Icatibant/std care

x

 C1 inhib./std care

x

 Std care

x

x

x

x

x

x

x

 CT of the chest

x

X (D14)

X (D28)

X

 Primary outcome

x

x

x

x

x

 Clinical symptoms

x

x

x

x

x

x

 Vital signs

x

x

x

x

x

x

x

x

 ECG

x

 Adverse events

x

x

x

x

x

x

x

x

 Time mechanical ventilation

x

 Death

x

 Length of stay

x

Laboratory tests*

RT-PCR SARS-CoV-2

x

 Bradykinin

x

x

x

 SOFA score

x

x

x

x

x

x

 Blood routine

x

x

x

x

x

x

 Coagulation routine

x

x

x

x

x

x

 CRP

x

x

x

x

x

x

 Liver function

x

x

x

x

x

x

 Kidney function

x

x

x

x

x

x

 d-dimer

x

x

x

x

x

x

 High-sensitivity troponin

x

x

x

x

x

x

 Pro-BNP

x

x

x

x

x

x

 Aspergillus antigen

x

x

x

x

x