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Table 1 Characteristics of included studies

From: Outcome reporting in neonates experiencing withdrawal following opioid exposure in pregnancy: a systematic review

First author (ref.)

Year

Intervention type

Intervention

Study type

Region of origin

Sample Size

Ebner [29]

2007

P

Morphine

PCS

Austria

53

Abrahams [30]

2007

NP

Rooming-in

RCS

Canada

106

Mazurier [31]

2008

P

Morphine

CS

France

37

Colombini [32]

2008

P

Morphine

PCS

France

22

Jansson [33]

2008

NP

Breast feeding

PCS

USA

16

Kraft [34]

2008

P

Sublingual buprenorphine

RCT

USA

26

Agthe [35]

2009

P

Clonidine

RCT

USA

80

Leikin [36]

2009

P

Clonidine

CS

USA

14

Abrahams [37]

2010

NP

Rooming-in

RCS

Canada

952

Saiki [38]

2010

NP

Postnatal ward

RCS

UK

60

Esmaeili [39]

2010

P

Clonidine and chloral hydrate

RCS

Germany

133

O’Mara [40]

2010

P

Clonidine

CR

USA

1

Isemann [41]

2011

NP

Breastfeeding

RCS

USA

128

Kraft [42]

2011

P

Sublingual buprenorphine

RCT

USA

24

McQueen [43]

2011

NP

Breastfeeding

RCS

Canada

28

Schwartz [44]

2011

NP

Auricular acupressure

RCT

USA

76

Backes [45]

2012

NP

Outpatient weaning

RCS

USA

121

Filippelli [46]

2012

NP

Noninsertive acupuncture

CS

USA

54

Murphy-Oikonen [47]

2012

NP

Clinical practice guideline

RCS

Canada

90

O’Connor [48]

2013

NP

Breastfeeding

RCS

USA

85

Welle-Strand [49]

2013

NP

Breastfeeding

Mixed method (RCS and PCS)

Norway

124

Surran [50]

2013

P

Clonidine adjunct

RCT

USA

68

Hall [51]

2014

P

Weaning protocols for morphine, methadone, buprenorphine

RCS

USA

547

Bhatt-Mehta [52]

2014

P

Methadone

RCS

USA

60

Smirk [53]

2014

NP

Home-based detoxification

RCS

Australia

118

Asti [54]

2015

NP

Implementation of standardized protocol

QI

USA

92

Hall [55]

2015

P

Methadone weaning protocol

PCS

USA

360

Liu [56]

2015

NP

Breastfeeding

RCS

Australia

194

Hall [57]

2015

P

Standardized weaning protocol

RCS

USA

981

Raith [58]

2015

NP

Laser acupuncture

RCT

Austria

28

Brown [59]

2015

P

Methadone

RCT

USA

31

Bada [60]

2015

P

Morphine

RCT

USA

31

Lee [61]

2015

NP

Combined in/outpatient

RCS

USA

139

Nayeri [62]

2015

P

Phenobarbital

RCT

Iran

60

Young [63]

2015

P

Oral morphine

RCS

USA

26

Newman [64]

2015

NP

Rooming-in

PCS

Canada

45

Kelly [65]

2015

NP

Home weaning

RCS

Canada

80

Hall [66]

2016

P

Buprenorphine

RCS

USA

201

Ibach [67]

2016

P

Methadone

RCS

USA

50

Hahn [68]

2016

NP

Massage

Qualitative thematic analysis

USA

8

Holmes [69]

2016

NP

Rooming-in

QI

USA

163

Short [70]

2016

NP

Breastfeeding

RCS

USA

3725

Patrick [71]

2016

NP

Evidence-based practice guidelines

QI

USA

3458

Kraft [72]

2017

P

Buprenorphine

RCT

USA

63

Zuzarte [73]

2017

NP

Vibrotactile stimulation

Prospective within-subject study

USA

26

Grossman [74]

2017

NP

Standardization and inpatient unit

QI

USA

287

Howard [75]

2017

NP

Parental presence

RCS

USA

86

  1. CR case report, CS case series, NP non-pharmacologic, P Pharmacologic, PCS prospective cohort study, QI quality improvement, RCS retrospective cohort study, RCT randomized controlled trial