Table 1 Time schedule for the in-hospital clinical trial

From: Jakyakgamcho-tang in the relief of delayed-onset muscle soreness in healthy adults: study protocol for a randomized, double-blind, placebo-controlled, crossover design clinical trial

Day	Day 1				Day 2				Day 3			Day 4
Time points	15:00	17:00	18:00	19:00	00:00	6:00	12:00	18:00	6:00	12:00	18:00	6:00	12:00	18:00	19:00
Time after exercise		–1 h	0 h	1 h	6 h	12 h	18 h	24 h	36 h	42 h	48 h	60 h	66 h	72 h
Blood pressure		○		○		○		○	○		○	○		○
Check for adverse events				○		○		○	○		○	○		○
Physical examination	○
Body composition analysis	◎
IPAQ-SF questionnaire	◎
Treadmill exercise			○
Medication				○		○	○	○	○	○	○	○	○
Randomization			○
Blood tests		○												○
Serum CK analysis		○				○		○			○	○		○
Serum CRP, IL-6		○	○	○	○	○		○
Pain intensity assessments		○	○	○	○	○		○	○		○	○		○
Calf circumferences		○	○	○	○	○		○	○		○	○		○
Pain threshold		○	○	○	○	○		○	○		○	○		○
Serum & urine collection		○		○										○
Blind assessment															○

◎ Assess only at the first hospitalization (Phase I)
IPAQ-SF International Physical Activity Questionnaire-Short Form, CK creatine kinase, CRP C-reactive protein, IL-6 interleukin-6

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