Table 1 A TAPER-S study timeline

Screening and Randomization

 V0 – Days -3 to -1

  Signed and dated Informed Consent obtained prior to start any procedure scheduled for the study

  Verification and confirmation of the inclusion/exclusion criteria

  Randomization

  Demographics, medical history

  Physical Examination

  Vital Signs (BP, HR)

  NYHA Class definition

  Pregnancy Test (serum test or urine test as per decision of the clinician)

  Full Blood Count, Chemistry and Coagulation Tests

  ECG

  Echocardiography, if not performed within the last year from the Informed Consent signature

  Chest X-Ray

  VASP and VerifyNow Test

  Dyspnea Evaluation

  Drug Dispensing

  Drug Accountability

  Concomitant Medications

  Adverse Events

Index PCI

 V1 – Day 0

  Verification and confirmation of the inclusion/exclusion criteria

  Vital Signs (BP, HR)

  ECG

  Ischemic Preconditioning

  Quantification of coronary microvascular resistance

  VASP and VerifyNow Test

  VAS Scale Evaluation

  Dyspnea Evaluation

  Drug Dispensing

  Drug Accountability

  Concomitant Medications

  Adverse Events

Follow-up

 V2 – Day 1

  Physical Examination

  Vital Signs (BP, HR)

  ECG

  VASP and VerifyNow Test

  Dyspnea Evaluation

  Drug Dispensing

  Drug Accountability

  Concomitant Medications

  Adverse Events

Pre-discharge Visit

 V3 – Day 2

  Physical Examination

  Vital Signs (BP, HR)

  Dyspnea Evaluation

  Drug Dispensing

  Drug Accountability

  Concomitant Medications

  Adverse Events

Discharge/End of Study Visit

 V4 – Day 3 to Day 5

  Physical Examination

  Vital Signs (BP, HR)

  ECG

  Full Blood Count, Chemistry and Coagulation Tests

  Dyspnea Evaluation

  Drug Dispensing

  Drug Accountability

  Concomitant Medications

  Adverse Events