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Table 1 Strengths and weaknesses of human and in silico imaging clinical trials

From: In silico imaging clinical trials: cheaper, faster, better, safer, and more scalable

Human trial

In silico trial

+ Real-world device usage

−Approximation

− Limited samples

+ Unlimited samples

− Large variability

+ Adjustable variability

− Narrow scope

+ Broader scope

− Truth uncertain

+ Truth known exactly

− Risk to patients

+ No patient risk

− Burdensome

+ Less burdensome