Fig. 2

Participant pathway into the FLAIR trial during stage 2. The experimental arms (IR and I+V) are shown in green and the control arms (FCR and I) in purple.

The primary objectives are:

•To assess IR vs FCR in terms of PFS

•To assess I+V vs FCR in terms of PFS

•To assess I+V vs I or IR, as appropriate, in terms of MRD negativity rate at 24 months post-randomisation