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Fig. 4 | Trials

Fig. 4

From: Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia

Fig. 4

Comparison of methods to measure hydroxyurea concentrations. The novel LC-MS/MS method of hydroxyurea measurement was validated in comparison to the more standard HPLC technique. a The excellent correlation (r = 0.92) with individual hydroxyurea concentrations. b The correlation is similarly strong (r = 0.90) when each patient’s samples are combined using both measure to calculate hydroxyurea area under the concentration-time curve (AUC)

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Trials

ISSN: 1745-6215