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Fig. 2 | Trials

Fig. 2

From: The TIRS trial: protocol for a cluster randomized controlled trial assessing the efficacy of preventive targeted indoor residual spraying to reduce Aedes-borne viral illnesses in Merida, Mexico

Fig. 2

Proposed design for the TIRS trial. A possible arrangement of clusters within Merida, obtained using variable-constrained randomization. The final arrangement will be generated prior to household enrollment. Inset shows city blocks in yellow (the extent of the 5 × 5 cluster) with blue blocks showing the area where epidemiological and entomological evaluations will be concentrated (“fried egg” design). Blue lines in the lower panel show the 30-year average DENV case distribution by month, repeated on each trial year

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