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Table 2 Sample size calculation

From: Can low-dose methotrexate reduce effusion-synovitis and symptoms in patients with mid- to late-stage knee osteoarthritis? Study protocol for a randomised, double-blind, and placebo-controlled trial

 

Mean (SD)

Detectable difference

Calculated sample size (per arm)

Suprapatellar pouch effusion (cm2)

2.0 ± 1.5

35%

74

VAS knee pain (0–100)

50 ± 20

20%

64

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Trials

ISSN: 1745-6215