Timing of antiretroviral therapy for HIV-infected patients with moderate to severe Pneumocystis pneumonia: study protocol for a multi-centre prospective randomised controlled trial

Table 1 Measurement items and point of data capture

	Visit 1	Visit 2	Visit 3	Visit 4	Visit 5	Visit 6	Visit 7
	Baseline	Week 4	Week 8	Week 12	Week 24	Week 36	Week 48
Signed consent	×
Enrolment	×
Demography	×
Signs and symptoms	×	×	×	×	×	×	×
Haematological analysis	×	×	×	×	×	×	×
Urinalysis	×	×	×	×	×	×	×
Clinical chemistry studies	×	×	×	×	×	×	×
Serum amylase levels	×
Myocardial enzymes	×
Blood gas analysis	×
1,3β-D-glucan	×
Urine pregnancy test	×
Lymphocyte subset	×	×	×	×	×		×
Quantitative plasma HIV-1 RNA	×				×		×
Chest CT/X-ray	×	×	×	×	×	×	×
IRIS		×	×	×	×	×	×
Drug combination	×	×	×	×	×	×	×
Adverse events		×	×	×	×	×	×

Abbreviations: CT computed tomography, HIV-1 human immunodeficiency virus 1, IRIS immune reconstitution inflammatory syndrome

ISSN: 1745-6215