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Table 3 Timolol dosage management

From: Beta-adrenergic antagonist for the healing of chronic diabetic foot ulcers: study protocol for a prospective, randomized, double-blinded, controlled and parallel-group study

Wound size (cm2)

Number of drops

Timolol dosage (mg/day)

Timolol dosage (mL/day)

Note: 1 drop = 0.05 ml

Dosage for 12-week supply (ml)

Number of bottles (timolol or placebo) dispensed to patient for 12-week supply (1 bottle = 5 ml)

< 0.5

1

0.25

0.05

4.2

1

> 0.5–0.9

1

0.25

0.05

4.2

1

> 1.0–1.9

1

0.25

0.05

4.2

1

> 2.0–2.9

2

0.5

0.1

8.4

2

> 3.0

3

0.75

0.15

12.6

3