Table 1 Exclusion criteria

 Related to the diagnosis

1) Crohn’s disease, ulcerative colitis, treatment with an immunosuppressive therapy

2) Patients who received an adaptive dose of levofloxacin 250 mg/24 h instead of 500 mg/24 h, preoperatively or perioperatively (notably for patients with creatinine clearance ≤ 50 ml/min), or who have an allergy to metronidazole or one of the excipients and/or who have a contra-indication for the use of ceftriaxone (hypersensitivity to the active substance, to another cephalosporin, to the excipient of the used drug) or who have a history of severe hypersensitivity (such as anaphylactic shock) or hypersensitivity to another antibiotic of the beta-lactam family (penicillin, monobactam, carbapenems) or who have a contraindication for the use of levofloxacin, hypersensitivity to levofloxacin, another quinolone, or the excipient of one of the used drugs, hypersensitivity to levofloxacin or any other quinolone or any excipient, a history of epilepsy, or a history of tendinitis when injected with fluoroquinolones

 Related to the severity of the appendicitis

1) Severe sepsis, septic shock, or generalized peritonitis^a

 Related to the treatment

1) A decision to perform open appendectomy or a conversion to open surgery

 Related to the severity of the appendicitis

1) Non-complicated forms (catarrhal appendicitis or the absence of extraluminal fecaliths, abscess, or peritonitis)

2) Generalized purulent or stercoral peritonitis (the presence of pus or feces in more than two quadrants of the abdomen)