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Table 4 Timing of interim analyses

From: The design and statistical aspects of VIETNARMS: a strategic post-licensing trial of multiple oral direct-acting antiviral hepatitis C treatment strategies in Vietnam

  First Second Third Fourth
Months since recruitment started 7 10 13 18
Total recruited 205 361 517 777
Total at EOT + 12 weeks 44 144 286 533
At EOT + 12 weeks in each:
 PEG-IFN group 5 14 24 42
 RGT group 3 11 21 39
 Induction/maintenance group 2 8 17 35
Average probability genuinely inferior group will be stoppeda
 PEG-IFN groups 0.124 0.297 0.537 0.710
 RGT groups 0.021 0.313 0.440 0.665
 Induction/maintenance groups 0.070 0.150 0.431 0.593
  1. Abbreviations: EOT + 12 12 weeks after the end of treatment, PEG-IFN pegylated-interferon, RGT response-guided therapy
  2. a Assuming true cure rate uniformly distributed over 60–90%