Time point from enrollment | Starting (study day 1) dose mg/day | |||
---|---|---|---|---|
≥ 30 | < 30 to 15 | < 15 to 5 | < 5 to 1 | |
Days 2–7 | 30 | Continue dose | Continue dose | Continue dose |
Days 8–14 | 20 | 15 | 10 (or continue dose if < 10) | 2.5 (or continue dose if < 2.5) |
Days 15–21 | 15 | 10 | 7.5 (or continue dose if < 7.5) | 2.5 (or continue dose if < 2.5) |
Days 22–28 | 10 | 7.5 | 5 | 1 |
Days 29–34 | 7.5 | 5 | 2.5 | 0 |
Days 35–40 | 5 | 2.5 | 1 | 0 |
Days 41–48 | 2.5 | 1 | 0 | 0 |
Day 49 | 0 | 0 | 0 | 0 |