Table 1 Inclusion criteria for the Onkyeong-tang (OKT) clinical trial

1. Female patients between the ages of 19 and 59 years with a complaint of cold hypersensitivity in the feet (CHF)

2. Patients must meet at least one or more of the following conditions:

2.1. Symptoms of CHF at a temperature at which most individuals do not feel cold

2.2. Symptoms of severe CHF during exposure to colder than normal temperature

2.3. Persistent CHF symptoms even after returning to a warmer environment

3. The patient’s Visual Analog Scale score for CHF should be 4 or more

4. Thermal deviation between the foot (acupuncture point, LR3) and thigh (acupuncture point, ST32) should be higher than 2 °C when both the lower legs are exposed to room temperature (24 °C ± 2)

5. Patients should be able to give informed consent