Table 3 Schedule of assessments

 Eligibility screening as appropriate (as per standard care), e.g., ANC, AST/ALT, creatinine, blood culture. When available, Hb, platelets, CRP, albumin, lactate

X

 Informed consent obtained

x

 Eligibility screening as appropriate (non-standard care) e.g., pregnancy test, MASCC score, max temp prior to randomisation, signs/symptoms of sepsis

x

 EQ-5D-5 L

x

 Standard care antibiotic administration

X

x

x

x

x

 Intervention (early switch) antibiotic administration (IV antibiotics will commence prior to informed consent)

X

x

x

x

x

 Research blood sample

x

 GP letter sent

x

 Demographics, vital signs, cancer, medical and SACT history, hospital admission details

x

 Concomitant medications

x

x

x

x

x

 Relevant microbiological results

x

x

x

x

x

 Antibiotic regimen

X

x

x

x

x

x

 Highest daily temperature (whilst inpatient or temperature recorded if unwell as an outpatient)

X

x

x

x

x

x

 Adherence to protocol specified intervention

x

x

 Survival status

x

x

 EQ-5D-5 L

x

 Patient follow-up questionnaire

x

 New medications

x

x

 Changes to next planned SACT cycle

x

 Hospital discharge/re-admission/critical care admission details

x

x

 Recording and reporting of adverse events

x