Table 4 Summary of re-executions of the Collaborative Ankle Support Trial using each Bayesian design

Proportion stopping for efficacy at 200 patients

NA

0.216

0.148

0.166

0.147

0.072

Proportion stopping for efficacy at 400 patients

NA

0.043

0.011

0.017

0.011

0.004

Proportion stopping for futility at 200 patients

NA

0

0

0

0

0

Proportion stopping for futility at 400 patients

NA

0

0

0

0

0

Proportion re-executions declared successful at final analysis

0.855

0.894

0.835

0.865

0.877

0.23

Proportion re-executions tubular bandage (control) declared best at final analysis

0

0

0.001

0

0

0

Proportion re-executions boot declared best at final analysis

0.054

0.057

0.085

0.036

0.021

0.007

Proportion re-executions brace declared best at final analysis

0.437

0.402

0.43

0.451

0.481

0.432

Proportion re-executions below-knee cast declared best at final analysis

0.509

0.541

0.484

0.513

0.498

0.561

Median (IQR) of the posterior mean estimates for tubular bandage

54.25 (52.70–55.68)

53.72 (51.90–55.46)

54.40 (52.99–55.74)

53.91 (52.52–55.30)

53.97 (52.64–55.33)

52.49 (51.68–52.96)

Median (IQR) of the posterior estimates of the difference in means between boot and tubular bandage

5.60 (3.65–7.48)

6.00 (4.02–8.25)

5.65 (3.75–7.56)

4.77 (2.42–6.84)

4.85 (2.58–7.05)

6.42 (3.98–8.15)

Median (IQR) of the posterior estimates of the difference in means between brace and tubular bandage

8.60 (6.52–10.63)

8.66 (6.67–10.89)

7.62 (4.81–10.22)

8.48 (5.65–10.71)

8.67 (5.99–10.73)

9.64 (6.01–11.66)

Median (IQR) of the posterior estimates of the difference in means between below-knee cast and tubular bandage

8.70 (6.86–10.91)

9.69 (7.22–13.29)

8.06 (5.44–10.53)

8.79 (6.57–11.39)–

8.68 (6.58–11.27)

10.57 (8.69–11.78)