Skip to main content

Table 4 Summary of re-executions of the Collaborative Ankle Support Trial using each Bayesian design

From: Bayesian adaptive designs for multi-arm trials: an orthopaedic case study

 Design 1Design 2Design 3Design 4Design 5Design 6
Proportion stopping for efficacy at 200 patientsNA0.2160.1480.1660.1470.072
Proportion stopping for efficacy at 400 patientsNA0.0430.0110.0170.0110.004
Proportion stopping for futility at 200 patientsNA00000
Proportion stopping for futility at 400 patientsNA00000
Proportion re-executions declared successful at final analysis0.8550.8940.8350.8650.8770.23
Proportion re-executions tubular bandage (control) declared best at final analysis000.001000
Proportion re-executions boot declared best at final analysis0.0540.0570.0850.0360.0210.007
Proportion re-executions brace declared best at final analysis0.4370.4020.430.4510.4810.432
Proportion re-executions below-knee cast declared best at final analysis0.5090.5410.4840.5130.4980.561
Median (IQR) of the posterior mean estimates for tubular bandage54.25 (52.70–55.68)53.72 (51.90–55.46)54.40 (52.99–55.74)53.91 (52.52–55.30)53.97 (52.64–55.33)52.49 (51.68–52.96)
Median (IQR) of the posterior estimates of the difference in means between boot and tubular bandage5.60 (3.65–7.48)6.00 (4.02–8.25)5.65 (3.75–7.56)4.77 (2.42–6.84)4.85 (2.58–7.05)6.42 (3.98–8.15)
Median (IQR) of the posterior estimates of the difference in means between brace and tubular bandage8.60 (6.52–10.63)8.66 (6.67–10.89)7.62 (4.81–10.22)8.48 (5.65–10.71)8.67 (5.99–10.73)9.64 (6.01–11.66)
Median (IQR) of the posterior estimates of the difference in means between below-knee cast and tubular bandage8.70 (6.86–10.91)9.69 (7.22–13.29)8.06 (5.44–10.53)8.79 (6.57–11.39)–8.68 (6.58–11.27)10.57 (8.69–11.78)
  1. IQR interquartile range, NA not applicable