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Table 1 Composition and action of Yishen Tongbi decoction

From: Evaluating the therapeutic efficacy of the Chinese herbal medicine Yishen Tongbi decoction in patients with active rheumatoid arthritis: protocol for a randomized, controlled, noninferiority trial

Ingredient

Action (TCM)

Pharmacological effect

Fructus Ligustri Lucidi (nvzhenzi)

Nourishing the liver and kidney

Improving bone metabolism and bone quality

Antiosteoporotic

Herba ecliptae (mohanlian)

Nourishing the liver and kidney

Inhibiting osteoclast proliferation and differentiation

Eucommia ulmoides Oliver (duzhong)

Nourishing the liver and kidney

Strengthening tendons and bones

Preventing miscarriage

Suppressing the proliferation of synoviocytes

Increasing the anti-inflammatory effects of interleukin-10

Inhibiting the serum and tissue levels of key pro-inflammatory cytokines

Reducing the degradation of cartilages and bones

Fructus lycii (gouqizi)

Nourishing the liver and kidney

Strengthening and nourishing marrow and essence

Improving eyesight

Antiosteoporotic

Anti-inflammatory

Immunomodulatory

Salvia miltiorrhiza Bge (danshen)

Promoting blood circulation for removing blood stasis

Clearing heart fire

Tranquilization method

Anti-inflammatory

Antiallergic

Immunosuppressive

Tripterygium hypoglaucum (Levl.) Hutch (kunmingshanhaitang)

Dispelling pathogenic wind and removing dampness

Relieving rigidity of muscles and activating collaterals

Anti-inflammatory

Immunosuppressive

  1. The content in parenthese is the Chinese spelling
  2. TCM traditional Chinese medicine