Table 2 IMPs in the COSMO-PD trial
Intervention | Chlorhexidine gluconate | Mupirocin ointment | Usual care with normal saline dressing |
|---|---|---|---|
Description of IMPs | Non-ionized cloth impregnated with 2% chlorhexidine gluconate (Ion PAD PLUS CHG2®, Pose Health Care., Ltd.) | 2% mupirocin calcium ointment (Charoon Bhesaj Co., Ltd.) | Isotonic solution, 0.9% sodium chloride irrigation USP (A.N.B. Laboratories Co., Ltd.) |
Packaging | Non-rinse, disposable, single use in plastic sachet | 5-g ointment tube | Plastic bottle container 500 mL, sterile and non-pyrogenic |
Dummy placebo | Identical placebo ointment tube | Identical plastic sterile non-ionized patch sachet | Identical both placebo ointment tube and placebo plastic sterile non-ionized patch sachet |
Administration | Wiping over PD catheter exit site after dressing with normal saline solution, then applying with placebo ointment base by participants or their caregivers, once daily. | Daily applying to PD catheter exit site by participants or their caregivers after dressing with normal saline and wiping with placebo sterile non-ionized patch, respectively | Daily dressing exit site with normal saline solution by participants or their caregivers, then wiping with placebo sterile non-ionized patch and applying with placebo ointment base, respectively |
Duration | Over a 24-month period | Over a 24-month period | Over a 24-month period |