Table 1 SPIRIT flow diagram of the NAMS study

Month

−4 (max)

−1

0

3

9

15

18

Informed consent

x

Demographics

x

Inclusion/exclusion criteria

x

x

x

x

x

x

x

Case history

x

Medication

x

x

x

x

x

x

x

Vital signs

x

x

x

x

x

Bioelectrical impedance analysis

x

x

x

Anthropometric data

x

x

x

x

x

x

Hand grip strength

x

x

x

Safety laboratory

x

x

x

x

x

Research laboratory

x

x

x

Urine sample

x

x

x

x

x

Stool sample

x

x

x

Multiple Sclerosis Quality of Life-54

x

x

x

Questionnaire on activities

x

x

x

Beck Depression Inventory II

x

x

x

Fatigue Severity Scale

x

x

x

Physical examination

x

x

x

Multiple Sclerosis Functional Composite

x

x

x

Symbol Digit Modalities Test

x

x

x

Six-minute walk test

x

x

x

Expanded Disability Status Scale

x

x

x

Relapse query

x

x

x

x

x

x

x

AE/SAE query

x

x

x

x

x

x

MRI

x

x

x

Four-day food record

x

x

x

Nutritional counseling

x

*

*

*

*