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Table 1 Detailed schedule of the RESTEP trial

From: Variable- versus constant-frequency deep-brain stimulation in patients with advanced Parkinson’s disease: study protocol for a randomized controlled trial

ScheduleBaselineVisit
ScreeningUpgradingEG for VFS, CG for CFSEG for VFS, CG for VFSEG for VFS, CG for VFS
Time3 ± 2 days5 ± 2 days90 ± 14 days90 ± 14 days180 ± 14 days
Follow-upV1V2V3V4V5
Informed consentX    
Criteria for inclusionX    
Criteria for exclusionX    
MMSEX X X
Hoehn-Yahr stagingX    
Medical history/demographic dataX    
Physical examinationX    
Records of side effectsXXX X
PDQ-39X X X
FOG-QX X X
GAFQX X X
MedicationX X X
UPDRS (part I/II/IV)X X X
Upgrade to dual mode X   
Random grouping X   
ProgrammingXXXXX
SWS testXXXXX
UPDRS (part III)XXXXX
Admission confirmedX    
AE XXXX
SAE XXXX
  1. AE adverse event, CFS constant-frequency stimulation, CG control group, EG experimental group, FOG-Q Freezing of Gait Questionnaire, GAFQ Gait and Falls Questionnaire, MMSE Mini-Mental State Examination, PDQ-39 Parkinson’s Disease Questionnaire-39, SAE serious adverse event, SWS stand–walk–sit, UPDRS Unified Parkinson’s Disease Rating Scale, VFS variable-frequency stimulation