The effect of an educational program for pregnant women to prevent allergic diseases in infants: study protocol for a randomized controlled trial

Table 2 Consent, enrolment/allocation, and assessment of subjects (Additional file 2)

	Study period
	Enrollment Allocation	Post allocation
Time point	Early pregnancy	20 weeks of pregnancy	30 weeks of pregnancy	Delivery	Discharge	1 month after delivery	4 months after delivery	12 months after delivery
Enrollment/allocation:
Inclusion	●
Obtaining informed consent	●
Randomization	●
Baseline survey		●
Interventions:
Educational program		●	●
Established childbirth education		●	●
Assessments:
Questionnaire survey on living habits, awareness, and knowledge of mothers before and after pregnancy			●			●	●	●
Survey on the behavioral characteristics of mothers						●	●	●
Blood collection from mothers	●		●
Blood collection from infants (IgE and TARC)							●	●
Stratum corneum hydration of infants					●	●	●
TEWL of infants					●	●	●
Findings on the skin of infants (scoring atopic dermatitis (SCORAD)) [50]					●	●	●
Images of the skin of infants					●	●	●
Diagnosis of atopic dermatitis in infants							●	●
Diagnosis of food allergy in infants							●	●
Provision of moisturizer					●	●	●
Collection of the moisturizer container						●	●	●

Legend: IgE immunoglobulin E, SCORAD scoring atopic dermatitis, TARC thymus and activation-regulated chemokine, TEWL transdermal water loss

ISSN: 1745-6215