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Table 2 Between-group differences in change scores from baseline to discharge, 4 weeks, and 6 months (∆intervention-∆control)

From: A randomized controlled trial of the effect of supervised progressive cross-continuum strength training and protein supplementation in older medical patients: the STAND-Cph trial

Primary outcome

Baseline to 4 weeks

P

Baseline to discharge

P

4 weeks to 6 months

P

DEMMI, score (ITT)

−4.17 (−11.09;2.74)

0.24

−0.51 (−6.51;5.49)

0.87

2.97 (−2.81;8.76)

0.31

DEMMI, score (PP)

−1.00 (−9.28;7.27)

0.81

4.70 (−3.30;12.70)

0.25

1.55 (−2.86;5.95)

0.49

Secondary outcomes

 24-h activity measures (ActivPal)

  Upright time, h/day (ITT)

0.06 (−0.89;1.02)

0.90

−0.59 (−1.16;0.01)

0.046

0.21 (−1.18;160)

0.77

  Upright time, h/day (PP)

0.25 (−0.61;1.11)

0.57

−0.55 (−1.14;0.05)

0.07

−0.002 (−1.36;1.37)

1.00

  Lying/sitting, h/day (ITT)

0.03 (−1.02;1.09)

0.95

0.46 (−0.21;1.14)

0.18

−0.001 (−1.35;1.34)

0.99

  Lying/sitting, h/day (PP)

−0.09 (−1.08;0.90)

0.86

0.28 (−0.42;0.98)

0.44

−0.19 (−1.45;1.07)

0.77

  Steps, n (ITT)

472.48 (− 536.44;1481.41)

0.36

117.76 (−465.37;700.90)

0.69

339.12 (−1152.00;1830.25)

0.65

  Steps, n (PP)

999.19 (−23.88;2022.25)

0.05

303.02 (− 272.84;878.88)

0.30

44.59 (− 1658.60;1747.79)

0.96

   Adjusted for DEMMI and LOS

1033.40 (4.13;2062.66)

0.049

    

   Adjusted for DEMMI, steps, and LOS

1032.77 (3.60;2061.94)

0.049

    

 Physical performance measures

  KES, Nm/kg (ITT)

0.11(−0.02;0.24)

0.09

0.08 (−0.05;0.20)

0.24

−0.09 (− 0.20;0.02)

0.11

  KES, Nm/kg (PP)

0.13 (−0.02;0.29)

0.09

0.10 (−0.07;0.27)

0.23

−0.11 (− 0.23;-0.002)

0.047

  STS, n (ITT)

0.04 (−1.88;1.96)

0.97

0.33 (−1.22;1.87)

0.68

1.28 (−0.76;3.31)

0.22

  STS, n (PP)

−0.01(−2.29;2.27)

1.00

0.21(−1.96;2.39)

0.85

1.45 (−0.94;3.84)

0.23

  GS, m/s (ITT)

0.02(−0.06;0.10)

0.64

0.07(−0.003;0.15)

0.06

0.02(−0.06;0.11)

0.57

  GS, m/s (PP)

0.04(−0.07;0.15)

0.45

0.11(0.004;0.22)

0.04

0.02(−0.08;0.11)

0.74

  HG, kg (ITT)

0.49(−1.40;2.39)

0.61

1.86 (0.49;3.23)

0.008

0.17 (−1.46;1.80)

0.84

  HG, kg (PP)

0.75(−1.37;2.87)

0.48

2.05(0.32;3.77)

0.02

−0.28(−2.11;1.55)

0.76

  Barthel, score (ITT)

−0.09 (− 0.83;0.66)

0.82

− 0.26 (− 0.87;0.34)

0.40

0.30 (− 0.11;0.70)

0.16

  Barthel, score (PP)

0.44 (− 0.42;1.31)

0.30

0.02 (− 0.65;0.70)

0.94

0.20 (− 0.20;0.61)

0.33

  1. Unadjusted values are shown for all comparisons and adjusted values are shown where these differ from the unadjusted analyses. All values are given as mean (95% confidence interval). For the number of imputations at different time points for the primary and secondary outcomes please see Additional file 1
  2. ITT intention to treat (N = 85), PP per protocol (N = 18 in intervention group (only those compliant with the intervention); N = 26 in control group), DEMMI baseline value of De Morton Mobility Index, steps: baseline value of steps, LOS length of stay, KES knee extension strength, STS 30-s sit-to-stand, GS gait speed, HG hand grip strength, Barthel Barthel Index
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Trials

ISSN: 1745-6215