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Table 7 Prioritised list of research questions 11–21

From: What are the most important unanswered research questions in trial retention? A James Lind Alliance Priority Setting Partnership: the PRioRiTy II (Prioritising Retention in Randomised Trials) study

Overall ranking

Research question

11

What aspects of trial recruitment processes could be changed to improve retention?

12

What aspects of trial retention do participants perceive as burdensome, and how can these be addressed?

13

What influence does the relationship between trial staff and participants have on retention?

14

How does a sense of belonging or being part of something amongst trial participants affect retention?

15

What are the best approaches for designing and communicating information about trial retention for trial participants?

16

To what extent (if any) do studies that explore retention procedures before the main trial (i.e. feasibility study) lead to improvements in retention in the main trial?

17

What is the impact of timing, frequency, and duration of follow-up (e.g. questionnaires, clinic appointments) on retention?

18

What strategies (e.g. sending Christmas cards or saying ‘thank you’) make participants feel valued and how do they affect retention?

19

What are the best strategies for using participant incentives (e.g. monetary or non-monetary), and how should they be implemented (e.g. when should they be provided) when collecting information from participants in clinical trials?

20

How does continuity (e.g. seeing/speaking to the same staff) and consistency (e.g. of trial information) affect retention?

21

What behaviours of trial staff (e.g. being friendly) result in improved retention?