Table 2 Outcome assessment (total and by group)
Variable | Li/VPA group | Li/CBZ group | P value |
|---|---|---|---|
Clinical Global Impressions Scale modified for use in BP (CGI-BP) | 0.33** | ||
Week 0, average (standard deviation (SD)) | 3.8 (1.1) | 3.8 (1.1) | |
Week 8, average, SD | 2.7 (1.6) | 3.1 (1.5) | |
Within-group difference, P value*, Cohen’s d | 0.001, 0.80 | 0.057, 0.53 | |
CGI-BP - Depression | 0.89** | ||
Week 0, average (SD) | 3.2 (1.5) | 3.5 (1.7) | |
Week 8, average (SD) | 2.1 (1.1) | 2.5 (1.6) | |
Within-group difference P value*, Cohen’s d | 0.005, 0.84 | 0.014, 0.61 | |
CGI-BP - Mania | 0.18** | ||
Week 0, average (SD) | 3.2 (1.7) | 2.0 (1.4) | |
Week 8, average (SD) | 2.4 (1.4) | 1.9 (1.0) | |
Within-group difference, P value*, Cohen’s d | 0.001, 0.77 | 0.152, 0.41 | |
Depressive symptoms (Hamilton Depression rating Scale) | 0.36** | ||
Week 0, average (SD) | 19.2 (7.2) | 21.6 (7.3) | |
Week 8, average (SD) | 11.3 (7.2) | 11.5 (6.0) | |
Within-group difference, P value*, Cohen’s d | <0.001, 1.10 | <0.001, 1.51 | |
Manic symptoms (Young Mania Rating Scale) | 0.68** | ||
Week 0, average (SD) | 11.4 (6.2) | 11.1 (5.9) | |
Week 8, average (SD) | 8.7 (5.3) | 7.5 (5.2) | |
Within-group difference, P value*, Cohen’s d | 0.041, 0.47 | 0.023, 0.65 | |
Treatment response in 2 months, n (%) | 15 (45,5%) | 10 (37,0%) | 0.61** |
Treatment remission in 22 months, n (%) | 9 (27.2%) | 6 (22.2%) | 0.77** |