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Table 1 Washout periods

From: To evaluate the efficacy and safety of PLC in perimenopausal or postmenopausal women with Hot Flashes: study protocol for a randomized controlled trial

Therapy

Washout period

Hormone agents vaginally (e.g. ring, cream, gel, etc.)

≥ 1 week

Transdermal agents containing estrogen-only or estrogen/progestin

≥ 4 weeks

Oral estrogen or progestin

≥ 8 weeks

Intrauterine progestin

≥ 8 weeks

Progestin implants or a single estrogen injection

≥ 12 weeks

Estrogen pellets or progestin injections

≥ 24 weeks

Acupuncture or moxibustion

≥ 1 week

Herbal medication or pharmacopuncture

≥ 3 weeks