Skip to main content

Table 2 Schedule of visits, data collection, and follow-up

From: CASSETTE—clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation: study protocol for a randomised controlled trial

Timepoint

Day 1

Day 2

Day 3

Day 4

Day 5

Day 6

Day 7

Da y 10

Day 14

Day 15–89

Day 90

Enrolment

 Eligibility screen

X

          

 Informed consent

X

          

 Demographic details

X

          

 Clinical details

X

          

 Randomisation

X

          

Interventions

 Standard therapy (flucloxacillin/cefazolin or vancomycin/daptomycin)

X

X

X

X

X

X

X

X

Xa

Xa

 

 Clindamycin (if in combination group)

X

X

X

X

X

X

X

    

Assessments

 Blood cultures

  

X

 

Xb

 

Xb

    

 FBC, EUC, LFTs, CRP

X

 

X

 

X

 

X

 

X

  

 Check SIRS score

X

X

X

X

X

X

X

X

X

  

 Check vital observations

X

 

X

   

X

X

X

  

 Clinical progress assessment

X

 

X

   

X

X

X

Weekly if inpatient

X

 Vital status

  

X

   

X

X

X

X

X

 Additional data

          

X

  1. CRP C-reactive protein, EUC electrolytes, urea, and creatinine, FBC full blood count, IV intravenous, LFT liver function tests, SIRS systemic inflammatory response syndrome
  2. aThe usual duration of IV treatment for Staphylococcus aureus bloodstream infection is 14–42 days in adults and 7–14 days in children; 4–6 weeks of IV therapy may be necessary in children with infective endocarditis
  3. bIf day 3 blood culture is positive, repeat every 48–72 h until negative
Back to article page

Trials

ISSN: 1745-6215